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In addition, pre-treatment with the NEDD8-activating enzyme (NAE) inhibitor MLN4924 fully rescued from degradation, highlighting a functional requirement on NEDD8 conjugation, and hence implying the functional involvement of a Cullin-RING ligase (CRL) in the SP3N-induced degradation of FKBP12 35

1 The only adverse effect observed was a slight non-dose-related reduction in fertility at dose levels of 500 or 1,000 mg/kg/day (2.6 or 5.2 times the human mucolytic dose) in the Segment I study

Pastore, A., Piemonte, F., Locatelli, M., Lo Russo, A., Gaeta, L

The National Research Council (2006) outlined a classification scheme for biological measurements which we have adopted and adapted to the specific requirements of HBM of mycotoxins (Table 1)