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PAR: protease-activated receptor

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Lancet Oncol 21:893903 Pascutti MF, Erkelens MN, Nolte MA (2016) Impact of viral infections on hematopoiesis: from beneficial to detrimental effects on bone marrow output

and affecting the absorption of vitamin B12 in the body

Regarding physiological parameters, the accumulation of AGE-related protein content can lead to renal hemodynamic disorders and promote the progression of DKD (240)