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89 To more efficiently exert the function of nanozymes, Liu et al integrated Fe-isolated single-atom nanozyme (Fe-ISAzyme) liposome with TPP to the microneedles patch, and adapt in situ delivery

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EV + STC group (EV-transfected cells treated with STC)

Consequently, the combined modulation of the NRF2, AMPK, and NF-B pathways by an antioxidant-rich diet triggers an integrated protective mechanism that improves semen quality, reduces sperm DNA fragmentation, and enhances sperm fertilising ability, thus supporting the treatment of male infertility