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Glymphatic Stasis TBI disrupts the polarization of Aquaporin-4 (AQP4) channels, leading to "glymphatic stasis." The brain cannot clear its own waste, leading to the accumulation of toxic proteins (Tau, Amyloid) [7]

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In the HG-3 and MEC-1 cell lines, the inhibition of GLS-1 induced a dose-dependent decrease in cell proliferation, as detected using an MTS assay

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Effects of Testosterone Replacement on Muscle Mass and Muscle Protein Synthesis in Hypogonadal Mena Clinical Research Center Study. Journal of Clinical Endocrinology and Metabolism , vol