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Iron accumulation and lipid peroxidation constitute the main characteristics of ferroptosis, with a series of genes governing the antioxidant system, iron homeostasis and lipid metabolism orchestrating this cell death modality

Circ Res 2013;112:110411

The major problem is that no effective method exists to find the cause

The epidermis and dermis are the main layers, while the subcutaneous tissue mainly stores energy and maintains warmth ( Figure 2 The epidermis consists of various layers of epithelium, interfollicular epidermis, hair follicles, sebaceous glands, and eccrine sweat glands