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To name just one example, recent studies found significant NAD+ decreases in specific hypothalamic nuclei at 22 months in mice, while other regions kept their NAD+ levels steady

doi: 10.1113/jphysiol.2009.179325 59 LuHHuangDSaederupNCharoIFRansohoffRMZhouL

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What to limit, per Ramallo: Added sugar: Can worsen hormone balance and cycle irregularity (aim for 10g per serving) Alcohol: Highly dysregulatingkeeping intake under 12 drinks per day (or skipping it) can noticeably improve symptoms Caffeine: More than 23 servings daily may worsen symptoms for some people Supplements Under the guidance of a menopause-informed provider, certain supplements may help support cycles and symptoms, per Ramallo: Soy isoflavones: Support sex hormone balance, regulating cycles and reducing hot flashes Omega-3s: Excellent for hormone balance and cardiovascular health Vitamin D : Essential for hormone synthesis and regulation Inositol : Supports both sex hormones and insulin signaling Berberine & N-acetylcysteine (NAC): May help improve blood sugar regulation, especially impactful for people with insulin resistance Medical treatments Lifestyle supports are foundational, but sometimes symptoms need more backup