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Metformin was the most prevalent therapy (82%), followed by insulin (51%), glucagon-like peptide 1-receptor agonist (32%), SGLT2-i (23%), while patients prescribed dipeptidyl peptidase IV-inhibitors or sulfonylureas were less common (Table 1)

However, alcohol throws a wrench into the works by competing for the same processing pathways in the liver and causing amitriptyline to build up to potentially dangerous levels