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In the MSU-induced GA mouse model, complement C5a was secreted as a primary chemotactic signal for neutrophils (77), which could then bind to the G protein-coupled receptors to generate calcium ion flux (79), thereby mediating vesicle fusion with the cell membrane and promoting the secretion of exosomes coated with LTB4 (80)

Adenoviral Vectors cyto -EGFP, and mitochondrial GR mito -EGFP were first cloned into pDNR donor vectors (Clontech) and then inserted into the adenoviral vector by linear recombination using Cre recombinase (Invitrogen, Carlsbad, Calif)

When administered under professional supervision, glutathione is generally considered safe

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Disrupting insulin-like growth factor signaling as a potential cancer therapy