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doi: 10.1016/j.semarthrit.2013.03.004 [DOI] [PubMed] [Google Scholar] 331

mTOR and other effector kinase signals that impact T cell function and activity

The damage from freeze-thaw cycles comes from repeated freezing and thawing of the same solution, where ice crystals form, melt, reform, and melt again, each cycle physically stressing the peptide molecules