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More potent creams containing a mix of estrogen, especially estradiol over estriol (acknowledging that estriol is the predominant form in pregnancy) has a higher chance of flares

IGF-1 replacement therapy induced a restoration of the altered GH/IGF-1 axis by reducing circulating GH levels and recovering the somatostatinergic tone [292]

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In light of this dichotomy, novel targeted nanocomplexes have been developed to induce immunogenic cell death by specifically increasing RIPK3 phosphorylation and MLKL tetramerisation, thereby enhancing the cytotoxic effect of T cells on triple-negative breast cancer [60]