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Bangladesh Med Res Counc Bull

M., Hu, Z., Yip, M., Hart, L

A common and effective strategy is to take the divided doses approximately 20 to 30 minutes before a major meal

261, 262 Although high rates of efficacy were reported (47 to 64%), given the extremely small combined sample size of fewer than 30 patients, the relatively serious AEs (e.g., new diabetes onset, exacerbation of existing diabetes, pneumonia with septic shock, increased blood pressure), and the known risks of systemic long-term glucorticoid use, risks/burdens clearly outweigh benefits and the Panel recommends that this therapy not be used long-term

Consequently, the balance between xCT/GPX4 activity and ROS/iron/MDA levels determines cellular fate, with dysregulation tipping the scale toward ferroptotic cell death