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Mechanically, isoorientin increases the SIRT1 and SIRT6 expressions, promotes Nrf2 translocation, and activates the expression level of antioxidant enzymes, including HO-1 and NQO1 to inhibit the expression levels of NOX4 and ROS production, thereby reducing oxidative stress, alleviating mitochondrial dysfunction, and improving kidney injury of cisplatin-induced AKI mice

539 Glutamate transporter currents, which are a direct measure of the glutamate transport, decrease to ~15% of their level in young adult astrocytes

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