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About 90% of cases are sporadic and of unknown origin, while ~ 10% are familial (FALS)

10.1136/postgradmedj-2020-139065 181

doi: 10.1111/bpa.12426 208 LoisCGonzalezIIzquierdo-GarciaDZurcherNRWilkensPLoggiaMLet al

Copper deficiency and oxidative stress Copper deficiency has also been suggested to contribute to the development and progression of atherosclerosis via oxidative stress

A clinical study (NCT02848131) demonstrated that senolytic (D + Q) agents successfully clear senescent cells in diabetic nephropathy patients and significantly relieve the burden of senescent cells in adipose and skin tissues