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They also suggested that factors that alter the function of the blood-brain barrier (BBB), such as hypoxic or ischemic stroke, inflammation that causes endothelial upregulation of surface adhesion molecules, and disruption of the BBB barrier function by the cancer, may alter the penetration conditions and reduce the permeability of the drug through the BBB [24]

Its used on demand rather than daily, so cumulative exposure is limited compared with maintenance medications

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Este sndrome se asocia con plipos intestinales, en el intestino delgado, que pueden producir dolor u obstruccin intestinal, pero no se malignizan como ocurre con los plipos del Sndrome de Gardner

Patients and Methods Patients During the period from January 2023 to June 2023, patients undergoing excision of skin large congenital melanocytic nevi at the Department of Plastic Surgery were evaluated