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Sci Rep (2020) 10:21072

Its catabolism is closely linked to the progression of fibrosis [168]

Datta and Chattopadhyay, 2015)

Additionally, in vivo , Circular RNA CircP4HB expression levels are increased in LUAD, which inhibits ferroptosis by regulating miR-1184/SLC7A11-mediated GSH synthesis and, therefore protected LUAD cells from ferroptosis induced by erastin (Pan et al., 2022)

E3 ligases in metabolic diseases Insulin receptors and insulin receptor substrates (IRS-1 and IRS-2) are crucial for insulin signaling, and E3 ligases such as MG53, c-Cbl, and Nedd4 can directly degrade these substrates, disrupting signaling and promoting insulin resistance