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1996 Jun;2(3):161-71

However, these proportions shifted towards the control distribution following L-serine administration (Supplementary Fig

doi: 10.1371/journal.pgen.1005450 201 RckertC.EbelG

On the other hand, if reduced expression of a polynucleotide or polypeptide is desired, then the nucleic acid may be, e.g., an antisense oligonucleotide, siRNA, or microRNA that comprises a polynucleotide sequence that specifically hybridizes to a polynucleotide that encodes the target polypeptide, thereby disrupting expression of the target polynucleotide or polypeptide