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Moreover, it promotes degeneration of epithelial cells of the proximal convoluted tubule and tubular cylinders, enhances focal mineralization, damages podocytes of the Bowman's capsule, increases serum levels of urea and creatinine, and brings about histological changes in kidney tubules ( Figure 4 ) [77,84]

doi: 10.1016/j.bioteChadv.2023.108259 46 FutscherB

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Respective samples were analysed as described in HPLCMS/MS analysis for ADME and PK studies section in the Supplementary Information

Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function