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[DOI] [PubMed] [Google Scholar] 133.Solimini R, Rotolo MC, Mastrobattista L, Mortali C, Minutillo A, Pichini S, Pacifici R, Palmi I

Mechanistically, the histone acetyltransferase p300 showed a preference for deamidated H1 as a substrate, establishing H1 deamidation as a prerequisite for subsequent acetylation

Efforts are needed and being made by scientists to find more efficient while less toxic therapeutics for acute myeloid leukemia, as well as for cancers in general [42]

3.6.3 Epigenetic remodeling, therapeutic synergy, and nanodelivery potential Notably, emerging research indicates that polysaccharides can act as epigenetic modulators in cancer