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Neuroinflammation: A possible link between chronic vascular disorders and neurodegenerative diseases

Activated PGC-1 works synergistically with nuclear respiratory factors (NRF-1/2) and mitochondrial transcription factor A(TFAM) to drive mitochondrial DNA replication, ETC complex protein expression, and new mitochondrial generation, thereby enhancing the cells oxidative phosphorylation capacity and energy production (Liang et al., 2020)