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AEDG was reported to reduce DNA damage in neurons generated from fibroblasts, indicated by a drop in 8-hydroxydeoxyguanosine levels,

Phase 1 study of non-pegylated liposomal doxorubicin in children with recurrent/refractory high-grade glioma

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doi: 10.1002/mnfr.201500031

Conversely, both apoB100 and MTTP are negatively regulated by insulin, which reduces hepatic lipid export by inducing apoB100 degradation and suppressing MTTP synthesis [111]