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Nasal irritation or sneezing on intranasal use Reported practice alternates nostrils, allows time between sprays, and checks the formulation's preservative system

Slurred speech, confusion, dizziness, or a sudden severe headache: These could be signs of a stroke or another neurological emergency

Whether declining MOTS-c is a cause or consequence of this deterioration is still being resolved, but the correlation is striking enough that some researchers have proposed plasma MOTS-c as a biomarker of mitochondrial vitality and metabolic age