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This evidence has inspired the ligandin model for vacuolar sequestration of anthocyanins ( 1 ), in which arGSTs are believed to protect the labile anthocyanidins ( 3 ) from degradation and/or guide them from their biosynthetic origin on the cytoplasmic surface of the endoplasmic reticulum to transporters located on the tonoplast membrane 18,19,31

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[13] APX + H 2 O 2 Compound I + H 2 O [1] Formation of Compound II: Through a one electron reduction, Compound I is reduced by substrate (HS) to form Compound II

Due to heat and the pain, it would usually take longer for mice to lick their paws

The effectiveness of such an approach, particularly in achieving a significant reduction in pigmentation, tends to be limited