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Chuarienthong, P., Lourith, N., Leelapornpisid, P

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One mechanism involves the S-sulfhydation of OTU domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) at Cys91, which stabilizes the Xc light chain subunit (xCT), thereby promoting cystine uptake and maintaining GSH biosynthesis [77]

mtDNA is increasingly recognized as a pivotal mediator linking mitochondrial dysfunction to neuroinflammation in a broad range of neurological disorders

Targeted delivery of probiotics and their metabolites, based on the pathological link between intestinal microbiota metabolites and ferroptosis, may help inhibit ferroptosis, correct microbiota dysregulation, and restore immune homeostasis, offering a promising precision intervention strategy to alleviate IBD inflammation