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By attenuating NNMT activity, 5Amino1MQ has been observed in preclinical settings to elevate NAD+ availability, enhance metabolic flux, and upregulate downstream signaling programs associated with cellular stress responses and energy expenditure (e.g., SIRT1)

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Indeed, recent studies showed that, in addition to mediating ADCC in in vitro and ex vivo models, isatuximab and daratumumab directly activated NK cells and increased their lytic activity against tumor cells through CD16 and CD38 crosslinking [32, 33]