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Al examined how IGF-1 DES can potentially affect the cognitive function of aged rats by treating the excitatory synapses in the CA1 region of the hippocampus

Enhanced intestinal absorption of glucose results from increased sodium/glucose cotransporter (SGLT1) activity in enterocytes

The first signs of B12 deficiency include persistent fatigue, weakness, lightheadedness, pale skin, tingling or numbness in the hands and feet, difficulty concentrating, and mood changes like irritability or mild depression

Kulkarni, A., Muralidharan, C., May, S

However, when the scientists accounted for frailty and disease in their analysis, it did not substantially alter the results