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The analysis revealed that high-dose vitamin E ( 400 IU/day) was significantly associated with an increase in all-cause mortality, with a pooled risk difference of 39 additional deaths per 10,000 individuals

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The mechanism is indirect: more muscle preserved equals more calories burned at rest

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Although inconsistent with published data 13,27 , the negative effect of glucose on the lifespan of daf-16 worms, which we observe here, fits our model

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