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Despite mostly promising preclinical data, meta-analyses of clinical trials indicate that oxytocin treatment does not significantly improve impaired social and repetitive behaviors in adults with ASD [110], with only a moderate effect observed in children [111]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Paul B.D., Snyder S.H., Kashfi K

IGF-LR3 (Insulin-like Growth Factor 1, Long Arg3) is a synthetic IGF-1 analogue carrying a 13-residue N-terminal extension and an arginine swap at position 3. Together these changes sharply lower affinity for IGF-binding proteins, lengthening functional half-life and improving receptor availability making it a workhorse in proliferation and anabolic-signalling research