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Some of these proteins targets were also identified as autoantigens frequently recognized by autoantibodies in autoimmune diseases

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A randomized, double-blind, placebo-controlled trial with shift workers suffering from sleep disorders demonstrated that 5 mg melatonin taken before sleep over four weeks significantly improved sleep quality and cognitive performance, with notable reductions in fatigue and good tolerability, supporting the role of melatonin in managing NSW-related sleep issues 189

Upon H 2 O 2 treatment, ROS levels rapidly increased in WT MEFs, reaching a peak within 5-10 min (Fig