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Simultaneously, ROS activate PKC isoforms and the AGE-RAGE signaling cascade, which upregulate pro-inflammatory cytokines (TNF-, IL-6) and adhesion molecules (VCAM-1, ICAM-1) through NF-B activation (Gonzlez et al., 2023)

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doi:10.1093/toxsci/53.2.297 Cooper RL, Laws SC, Das PC, Narotsky MG, Goldman JM, Lee Tyrey E, Stoker TE (2007) Atrazine and reproductive function: mode and mechanism of action studies