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In that study, portal inflammation was shown to occur in HFE-hemochromatosis and was independently associated with the ductular reaction and fibrosis [91], demonstrating the potential mechanism of iron overload-induced injury and fibrogenesis in this condition

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Although limited information exists on the exact mechanisms, recent studies suggest passive diffusion as the primary mechanism for cellular uptake of natural curcumin, including clathrin-mediated endocytosis ( At low concentrations, curcumin primarily interacts with the polar heads of the outer membrane surface

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