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doi: 10.1177/1747493016662038 51

382 UVA upregulates the expression of COX-2 gene through MAPK/AP-1 mediated pathways

However, this reflects the case composition, since viral hepatitis and autoimmune hepatitis that comprised a large portion of the acute non-DILI liver injury group, are generally associated with higher liver profile values

Additionally, they exhibited a modest level of antiproliferative activity against the examined cell lines, with HeLa cells showing the most susceptibility among them

These modifications dramatically reduce binding affinity to IGF-binding proteins (IGFBPs) the regulatory proteins that normally sequester and deactivate circulating IGF-1