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However , scientific proof for this mainly applies to people who already have a deficiency

Journal of Endocrine Research, 29(1), 4553

Use semaglutide with caution in patients with known gallbladder disease or a history of cholelithiasis

It is contraindicated in certain conditions such as active malignancy and must be used cautiously in those with diabetes, prediabetes, or a history of pituitary disease, which is why careful screening and regular monitoring are essential

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