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The need for neuroprotection in HD is particularly urgent given the protracted presymptomatic phase, during which subtle cognitive and psychiatric changes may precede overt motor symptoms by years

10.1016/j.jtv.2019.02.003 46 DengY.ZhaoS.YangX.HouF.FanL.WangW.et al (2021)

PGR5 is required for NPQ and, concomitantly photosynthetic control so that plants deficient in the PGR5 protein undergo inhibition of PSI to a much larger degree when subjected to increases in light intensity (Munekage et al., 2002

Soon after this, in 1788, Thomas Crawley, another English physician, suggested on the basis of one of his clinical cases that diabetes might be linked to damage to the pancreas

While 75% or more of newborns with SCD in sub-Saharan Africa do not make their fifth birthday (McGann, 2014), in medium- to well-resourced countries almost all of affected babies can now expect to live to adulthood but overall survival still lags behind that of a non-SCD person by 2030 years (Telfer et al., 2007