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However, inhalation treatment with a low dosage of TP-10@CaP-CTP (2.5 mg/kg/2 days) or a high dosage of TP-10@CaP (7.5 mg/kg/2 days) ameliorated lung injury in the animals with chronic heart failure

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Since the nocturnal concentration of melatonin is approximately 310 times higher than the daily one (Odaci and Kaplan, 2009), the nocturnal application of the exogenous melatonin would be reinforced by the physiological peak of melatonin at night, thus leading to enhanced effects on regeneration according to Rateb et al

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