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The first generation JAK inhibitors have been approved for controlling CS in aGVHD and rheumatic diseases and showed efficacy in treating ARDS

The resulting gut dysbiosis is characterized by a loss of beneficial microbes ( Lactobacillus , Bifidobacterium ) and an expansion of pro-inflammatory pathobionts ( Escherichia-Shigella , Enterococcus ), which further fuels the inflammatory cycle ( F.n on the gut community is not limited to UC but also extends to CD, where specific populations like polymorphum are enriched, an effect more pronounced in male hosts ( The pathogenic role of F.n is even more pronounced in CRC, where it functions as a bona fide oncomicrobe

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The exquisite immune specificity for beta cells suggests that such cells may already harbour molecular signatures of vulnerability, which may act not only as initiators or conduits for the early immune response but also as amplifiers of ongoing beta cell-directed immune destruction (Kracht et al