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Likewise, resveratrol (3,5,4-trihydroxy-trans-stilbene), a polyphenolic compound found in grapes and wine that acts as a phytoestrogen (Gehm et al., 1997), can regulate the proliferation and neuronal differentiation of embryonic and adult NSPCs and human bone marrow-derived mesenchymal stem cells through the activation of protein kinase A (PKA)/glycogen synthase kinase 3 (GSK3)/-Catenin and PKA/ERK1/2 signaling pathways, as well as p38 kinases, sirtuin-1 (SIRT1) and AMP-activated protein kinase (AMPK) (Figure 3