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Orimo et al., 2011

Enhanced release of glucose into the intraluminal space of the intestine associated with metformin treatment as revealed by [(18)F]fluorodeoxyglucose PETMRI

These hurdles include the inherent complexity and significant inter-individual variability of the axis, challenges in achieving precise and safe interventions, and methodological barriers in clinical trial design and biomarker development, all of which impede rapid bench to bedside translation (163, 164)

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