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Types of Mutations ( + : decreased expression) or Nonsense mutation Nonsense mutation Types of Mutations ( 0 : absent expression) 2 types of disease variations: Thalassemia minor: heterozygous, approximately 50% decreased synthesis Synthesis Polymerase Chain Reaction (PCR) Thalassemia major: homozygous, no production of globulin, increase in HbA() and HbF(), no HbA Related videos Pathophysiology Defective Hb Hb The oxygen-carrying proteins of erythrocytes

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