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and whether the ammonia-rich microniches identified in hepatocellular carcinoma represent a phenomenon generalizable to other cancer types remains to be determined

16, 17 Under conditions of BH 4 deficiency, electron flow from the reductase domain to the oxidase domain is diverted to molecular oxygen rather than to L-arginine, a substrate of NO, leading to eNOS uncoupling

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GSH is synthesized via two enzymatic steps that are regulated at multiple levels