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Although beyond the primary scope of this review, it is worth mentioning that emerging evidence highlights the gut microbiome as a potential mediator of circadian disruption-associated breast carcinogenesis, with studies indicating that NSW can alter microbial composition and diurnal rhythmicity, thereby modulating systemic inflammation, estrogen metabolism, and immune function, all of which are relevant to BC risk 260

In order to study how the metabolism of APAP affects GSH concentration and resynthesis, we have connected the model depicted in Figure 1 to our extant model of glutathione metabolism [9]

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