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doi: 10.1016/j.chom.2010.10.005 14 MiagkovAVKovalenkoDVBrownCEDidsburyJRCogswellJPStimpsonSAet al

To define the two subtypes in functional assays, selective agonists and antagonists exist

Other preclinical investigations demonstrated positive benefits of SF on AD by attenuating A oligomers-mediated reduction of phagocytic activity (5 M for 24 h) (72), reducing streptozotocin-induced cognitive deficits (141 or 282 mol/kg/day for 6 weeks) (73), decreasing neuroinflammation and inhibiting tau phosphorylation (1 or 2 M for 1 h and stimulated with LPS for 23 h) (73), and reducing A production (226 mol/kg three times a week for 4 weeks) (74) in in vivo and in vitro AD models

It works by stimulating telomerase production from the pineal gland, an enzyme essential for maintaining the integrity of telomeres, the protective caps at the ends of chromosomes

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