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In addition, it directly modulates adaptive immunity by controlling effector T-cell expansion and activation (Ma et al., 2017)

For instance, microbial SCFAs, such as propionate, enhance BBB integrity by upregulating tight junction proteins (for example, occludin and claudin-5) and reducing systemic inflammation (103,135)

The risk of insertional mutagenesis historically associated with lentiviral vectors has been substantially reduced through the development of self-inactivating (SIN) vectors, in which the enhancer/promoter elements within the LTRs have been deleted

Auto-Abs can be of any Ab isotype, including immunoglobulin (Ig) A, IgE, IgM, IgE, and IgG [9], and potentially also IgD [10]

Halevy, I., Peters, S