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In cirrhosis the failure to properly replace destroyed hepatocytes and the excessive collagen deposition to distort blood flow through the liver (portal hypertension) result in severe liver dysfunction

doi: 10.1016/j.febslet.2014.10.003

Ferritin, responsible for iron storage, regulates intracellular iron by controlling ferritin synthesis and degradation (Galy et al., 2023

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These ICs molecules are ligand-receptor pairs that function as endogenous inhibitors to lower or eradicate inflammation after immune activation