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When methylation falters, homocysteine and SAH accumulate, limiting the production of cysteine and glutathione

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Excessive accumulation of toxic proteins induces endoplasmic reticulum stress to disrupt calcium homeostasis, activating the apoptotic pathway (Lim et al., 2023)

Prospective data published from the clinical trial ORATORIO, in a larger cohort of randomized and controlled primary progressive MS patients, showed that those experiencing PIRA had a significantly greater increase in fatigue (in all three MFIS subscales) than patients who did not 35