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3 Ferroptosis and neurodegenerative diseases Iron is an essential trace element for maintaining brain function, playing vital roles in neuronal development, neurotransmitter synthesis, mitochondrial energy metabolism, myelin formation, and synaptic plasticity (Gao et al., 2025)

Herniation usually occurs on the dorsal side, because the ventral part of the AF is two to three times thicker than the dorsal part and because the vertebral column is normally more flexed than extended, resulting in higher tension in the dorsal part than in the ventral part [2]