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Opening the BBB might ameliorate such problems by accelerating CPA diffusion from the vascular lumen to the neuropil and thereby reducing osmotic vascular distention

With a more exposed TIN2 TBM binding site and a native loop conformation adjacent to the site, the new P4 1 2 1 2 crystal system presented an opportunity to obtain more diverse, tractable fragment hits across the TIN2 TBM site, which could facilitate the NMR hit optimisation process through fragment growing, linking, and merging, and provide new hit matter

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