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although this is uncommon, any history of hypersensitivity to niacinamide or NAD would be a contraindication

doi: 10.1016/j.celrep.2021.108771 Summary Keywords childhood cancer, neuroblastoma, combination therapy, oxidative stress, DPI, MitoQ, metabolism Citation Epp S, Egan D, Poon E, Abdul Aziz AA, Wynne K, Chesler L, Halasz M and Kolch W (2025) Oxphos targeting of MYCN -amplified neuroblastoma

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When starting patients on therapy, it is important that baseline and ongoing renal and liver function tests are taken because renal disease or liver disease may be a primary complication of IBD itself[1]