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To tackle the hostile environment of the degenerated IVD, innovative tissue engineering approaches have been investigated to mimic the original IVD healthy microenvironment by combining cellular therapy, bio-scaffolds, and soluble molecules

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As early as 2003, Gangemi et al

The GluCEST approach can be instrumental in determining a genes effect on glutamate levels in the brain and can serve as a biomarker for detecting glutamatergic changes in ASD

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