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Nonetheless, this hypothesis requires further substantiation through more in-depth and direct evidence (see Table 2)

Oxidative stress and neuroinflammation significantly contribute to the pathophysiology of psychiatric disorders

Astrocytes sense extracellular changes through receptors such as pattern recognition receptors and cytokine receptors, detecting pathogens, A aggregates or inflammatory mediators 4,41

53 African populations demonstrate unique genetic advantages through higher frequencies of BCL2 protective variants promoting melanocyte survival, distinct ASIP gene polymorphisms affecting melanin production, and population-specific KIT ligand variants influencing MSCs maintenance

Remarkably, in terms of long-term impacts, the mice that received MSCs continuously maintained a 60%80% conception rate over a second breeding cycle, whereas the group treated with EXOs relapsed into infertility during the same period (Park et al., 2023)