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Cancer 5 , 6572 (2005)

Oxidative stress and disturbance in antioxidant balance in beta thalassemia major

Prog Neuropsychopharmacol Biol Psychiatry 2006;30:1039-42

For example, spermine is oxidized by spermine oxidase, producing H 2 O 2 and acrolein, an aldehyde that induces increased RBC membrane stiffness, increases osmotic sensitivity, and promotes eryptosis [123]